Story: Queen Chrysalis has captured Princess Celestia. Twilight and Cadence must rescue Celestia.
Special condition: Chrysalis and the two Changelings backing her up with randomly shapeshift into random MLP characters. The boss version of Chrysalis never uses Changeling Army. And she's susceptible to Bleeding.
Empowered Iso-8: Friendship Iso-8 (Twilight) - when Twilight shields an ally, she removes the ally's debuffs.
Lovely Iso-8 (Cadence) - both Magic attacks become Psychic Energy Attacks and cause Migraines.